Yes, Kamagra Jelly can interact with other medications and health conditions, which can affect its safety and efficacy. The primary active ingredient in Kamagra, sildenafil citrate, can interact with nitrates, commonly prescribed for angina or heart conditions, leading to a significant drop in blood pressure. Combining Kamagra with nitrates can be dangerous and is contraindicated. Other medications that can interact include certain antihypertensives, alpha-blockers, and some antifungal and antiviral drugs. These interactions can either increase the risk of side effects or reduce the effectiveness of Kamagra 100. Individuals with certain health conditions should also use Kamagra cautiously.